USMLE USMLE Q&A - in .pdf

  • USMLE pdf
  • Exam Code: USMLE
  • Exam Name: United States Medical Licensing Examination
  • Updated: Jul 21, 2026
  • Q & A: 400 Questions and Answers
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USMLE Step 2 is open to all medical students and graduates who have successfully passed the USMLE Step 1. The Step 2 exam assesses the candidates' medical knowledge, skills, and understanding of clinical science essential for patient treatment and care, health promotion and disease prevention.

USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

Reference: http://www.usmle.org/step-1/#question-formats

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USMLE USMLE Exam Syllabus Topics:

SectionObjectives
Hematopoietic and Lymphoreticular Systems- Blood and Immune Disorders
  • 1. Coagulation Disorders
  • 2. Anemias
  • 3. Leukemias and Lymphomas
Cardiovascular System- Cardiac and Vascular Disorders
  • 1. Vascular Pathology
  • 2. Heart Disease
Central and Peripheral Nervous Systems- Neurologic Disorders
  • 1. Neurologic Diseases
  • 2. Neuroanatomy
  • 3. Neuropathology
General Principles- Foundational Medical Sciences
  • 1. Immunology
  • 2. Genetics
  • 3. Pathology
  • 4. Physiology
  • 5. Behavioral Sciences
  • 6. Microbiology
  • 7. Biochemistry
  • 8. Pharmacology
Endocrine System- Hormonal Regulation and Disease
  • 1. Pituitary Disorders
  • 2. Adrenal Disorders
  • 3. Thyroid Disorders
Reproductive System- Male and Female Reproductive Health
  • 1. Reproductive Physiology
  • 2. Reproductive Disorders
Skin and Related Connective Tissue- Dermatologic Conditions
  • 1. Skin Neoplasms
  • 2. Inflammatory Skin Disorders
Human Development- Growth and Development
  • 1. Embryology
  • 2. Developmental Abnormalities
Musculoskeletal System- Bones, Joints, and Muscles
  • 1. Rheumatologic Diseases
  • 2. Orthopedic Disorders
Renal and Urinary System- Kidney and Urinary Disorders
  • 1. Renal Pathology
  • 2. Renal Physiology
Multisystem Processes and Disorders- Systemic Conditions
  • 1. Nutrition
  • 2. Neoplasia
  • 3. Infectious Diseases
Gastrointestinal System- Digestive System Disorders
  • 1. Gastrointestinal Pathology
  • 2. Liver Disease
Respiratory System- Pulmonary Medicine
  • 1. Lung Diseases
  • 2. Airway Disorders
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